{"id":327,"date":"2020-12-07T15:20:01","date_gmt":"2020-12-07T15:20:01","guid":{"rendered":"https:\/\/obgconnect.com\/curbside\/?p=327"},"modified":"2024-03-20T00:08:41","modified_gmt":"2024-03-20T00:08:41","slug":"is-it-bv-candidiasis-trich-a-practical-approach-to-making-the-diagnosis","status":"publish","type":"post","link":"https:\/\/obgconnect.com\/curbside\/2020\/12\/07\/is-it-bv-candidiasis-trich-a-practical-approach-to-making-the-diagnosis\/","title":{"rendered":"Is it BV? Candidiasis? Trich? A Practical Approach to Making the Diagnosis"},"content":{"rendered":"<h3 class=\"wp-block-heading\">Review the latest recommendations with Ashley Fuller, MD, FACOG, NCMP<\/h3>\n\n\n\n<p>Dr. Fuller is a gynecologist at Swedish Medical Group in Seattle, WA.&#xA0; She has a background in microbiology and immunology, with previous work in academic and industry research.&#xA0; Her practice focuses on vulvovaginal diseases and sexual health.<\/p>\n\n\n\n<p><strong>Learning Objectives:<\/strong> Upon completion of this activity, participants should be better able to<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Discuss the important components of the evaluation of vaginitis<\/li>\n\n\n\n<li>Formulate an evidence-based and practical approach to vaginitis evaluation in practice<\/li>\n\n\n\n<li>Describe current testing options and approach to make the diagnosis<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">CONTENTS:<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#case\">The Case<\/a><\/li>\n\n\n\n<li><a href=\"#synopsis\">Synopsis<\/a><\/li>\n\n\n\n<li><a href=\"#vaginitis\">Vaginitis Overview<\/a>\n<ul class=\"wp-block-list\">\n<li><a href=\"#bv\">Bacterial Vaginosis (BV)<\/a><\/li>\n\n\n\n<li><a href=\"#vvc\">Vulvovaginal Candidiasis (VVC)<\/a><\/li>\n\n\n\n<li><a href=\"#trichomoniasis\">Trichomoniasis<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><a href=\"#evaluation\">Evaluation<\/a>\n<ul class=\"wp-block-list\">\n<li><a href=\"#history\">History<\/a><\/li>\n\n\n\n<li><a href=\"#physical\">Physical Exam<\/a><\/li>\n\n\n\n<li><a href=\"#point-of-care\">Clinical &#x2018;Point of Care&#x2019; Testing<\/a><\/li>\n\n\n\n<li><a href=\"#laboratory\">Laboratory Testing<\/a><\/li>\n\n\n\n<li><a href=\"#commercial\">Commercial Testing<\/a><\/li>\n\n\n\n<li><a href=\"#criteria\">Recommended Diagnostic Clinical Criteria<\/a><\/li>\n\n\n\n<li><a href=\"#back-to-case\">Back to the Case<\/a><\/li>\n\n\n\n<li><a href=\"#wrap-up\">The Wrap-Up on Diagnostic Testing<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><a href=\"#references\">References<\/a><\/li>\n\n\n\n<li><a href=\"#related\">Related ObG Topics<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"case\">THE CASE:<\/h2>\n\n\n\n<p><em>Presenting History<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>32 y\/o G1P1\n<ul class=\"wp-block-list\">\n<li>Presents with concern regarding vaginal discharge that is thick and white<\/li>\n\n\n\n<li>Patient reports 2 weeks of vulvovaginal itching, burning, and discharge<\/li>\n\n\n\n<li>Tried OTC vaginal antifungal cream for the past few days which just burned and made it worse<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Gyn History\n<ul class=\"wp-block-list\">\n<li>Same male partner x 5 years<\/li>\n\n\n\n<li>Mirena IUD for contraception<\/li>\n\n\n\n<li>No history of recurrent vaginal infections but has had BV in the past<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"synopsis\">SYNOPSIS:<\/h2>\n\n\n\n<p>Vaginitis is inflammation or infection of the vagina associated with a spectrum of symptoms and a common reason for visits to both primary care doctors and OB\/GYNs.&#xA0; The majority of these infections will be due to bacterial vaginosis, candidiasis, or trichomoniasis, but noninfectious vaginitis does exist and is not uncommon.&#xA0; Accurate diagnosis is key as misdiagnosis can cause inappropriate treatment and recurrent visits. There are multiple diagnostic tools available so unfortunately diagnosis is not standardized.&#xA0; Below are key points to consider for the evaluation, diagnosis, and treatment of vaginitis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"vaginitis\">VAGINITIS OVERVIEW:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"bv\">Bacterial Vaginosis (BV)&#xA0;<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Most common diagnosis in patients presenting with vaginal symptoms, especially in reproductive age women\n<ul class=\"wp-block-list\">\n<li>26 to 30% <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Prevalence&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;In medicine, a measure of the total number of people in a specific group who have (or had) a certain disease, condition, or risk factor (such as smoking or obesity) at a specific point in time or during a given period of time. For example, the prevalence of breast cancer may show how many women in the U.S. were diagnosed with breast cancer within the past 10 years, including those who are receiving treatment and those who are considered cured, and are still alive on a certain date (NCI Dictionary)&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">prevalence<\/span> rate in the US with Black\/African American women and Mexican-American with higher rates than non-Hispanic women<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Associated with\n<ul class=\"wp-block-list\">\n<li>Preterm delivery<\/li>\n\n\n\n<li>Acquisition of STIs including HIV and PID<\/li>\n\n\n\n<li>Complications after gynecologic surgery<\/li>\n\n\n\n<li>Douching and sexual activity<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Pathophysiology\n<ul class=\"wp-block-list\">\n<li>Polymicrobial clinical syndrome where anaerobic bacteria (<em>Gardnerella vaginalis, Prevotella <\/em>sp<em>, Mobiluncus <\/em>sp, and numerous others) replace normal healthy vaginal <em>Lactobacillus <\/em>sp.&#xA0;<\/li>\n\n\n\n<li>The lack of hydrogen peroxide producing lactobacillus causes increase in pH<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Symptoms include\n<ul class=\"wp-block-list\">\n<li>Vaginal discharge | Fishy odor<\/li>\n\n\n\n<li>Many cases are asymptomatic<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Recurrence rate: 58% in 12 months<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"vvc\">Vulvovaginal Candidiasis (VVC) <\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Second most common diagnosis in patients presenting with vaginal symptoms\n<ul class=\"wp-block-list\">\n<li>75% of women will have at least one episode of VVC in their lifetime<\/li>\n\n\n\n<li>40 to 45% will have &gt;1 episode<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Most candida infections are caused by <em>Candida albicans<\/em> but other less common candida species can also cause symptomatic infections<\/li>\n\n\n\n<li>Symptoms of VVC include\n<ul class=\"wp-block-list\">\n<li>Thick, white discharge | Burning | Itching | Edema | Dyspareunia<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>10 to 20% of women will have complicated VVC, including recurrent, severe, or nonalbicans candidiasis<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"trichomoniasis\">Trichomoniasis<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Caused by the protozoan parasite <em>Trichomonas vaginalis<\/em>\n<ul class=\"wp-block-list\">\n<li>Most common nonviral STI in the United States<\/li>\n\n\n\n<li>13% of black women are affected compared with 1.8% of non-Hispanic white women | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;CDC&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Centers for Disease Control and Prevention&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">CDC<\/span> considers this gap in infection rates to be reflective of ongoing health disparities<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Associated with\n<ul class=\"wp-block-list\">\n<li>Increased number of sex partners<\/li>\n\n\n\n<li>Low socioeconomic status<\/li>\n\n\n\n<li>Douching<\/li>\n\n\n\n<li>Acquisition of other STIs including HIV, PID, posthysterectomy cuff cellulitis<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>50% asymptomatic<\/li>\n\n\n\n<li>Symptoms include\n<ul class=\"wp-block-list\">\n<li>Abnormal discharge | Itching | Burning | Postcoital bleeding | Vaginal or abdominal pain<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"evaluation\">EVALUATION:<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"history\">History&#xA0;<\/h3>\n\n\n\n<p><em>Symptoms: Questions to Ask<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Characterization: Itching, burning, irritation, dyspareunia, odor, discharge?\n<ul class=\"wp-block-list\">\n<li>Consider if symptoms sound more like BV, yeast, or other vaginitis etiology<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Location of symptoms: Vulvar, vaginal or anal?\n<ul class=\"wp-block-list\">\n<li>Consider vulvar or anal dermatologic conditions, such as lichen sclerosus or contact dermatitis<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Duration: Acute, chronic, or recurrent?\n<ul class=\"wp-block-list\">\n<li>Is this a new infection or similar to previous infections?<\/li>\n\n\n\n<li>If acute, did something recently change ie antibiotic course for unrelated infection, new sexual partner, new hygiene product?<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Systemic: Any fever, abdominal pain?\n<ul class=\"wp-block-list\">\n<li>Consider PID, UTI, pyelonephritis<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Urinary symptoms?\n<ul class=\"wp-block-list\">\n<li>Consider UTI<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Sexual History<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Number and gender ID of partners<\/li>\n\n\n\n<li>Sexual practices | Use of sex toys and washing practices\n<ul class=\"wp-block-list\">\n<li>New partner or same sex partner can be associated with BV | Sharing sex toys is associated with BV<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Medication History<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Any self-treatment with OTC products\n<ul class=\"wp-block-list\">\n<li>Did OTC treatment help or worsen symptoms?&#xA0;<\/li>\n\n\n\n<li>Could be azole resistant yeast<\/li>\n\n\n\n<li>If worsened consider wrong diagnosis or allergic reaction to OTC treatment<\/li>\n\n\n\n<li>Can make in-office microscopy more difficult if recent usage of vaginal cream as discharge often mixed with medication<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Hygiene Practices<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Use of detergents, soaps, daily pads\n<ul class=\"wp-block-list\">\n<li>Could be associated with contact dermatitis or allergic reaction<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Douching, shaving\n<ul class=\"wp-block-list\">\n<li>Could be associated with BV<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Underlying Medical Conditions<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Diabetes | Contact dermatitis or skin conditions | HIV | Inflammatory bowel disease\n<ul class=\"wp-block-list\">\n<li>Uncontrolled diabetes associated with yeast<\/li>\n\n\n\n<li>Other skin conditions could make them more likely to have vulvar skin conditions such as eczema<\/li>\n\n\n\n<li>HIV infected patients more susceptible to opportunistic infections<\/li>\n\n\n\n<li>IBD can be associated with vulvar Crohn&#x2019;s disease<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Relation of Symptoms to Menstrual Cycle<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hormonal changes that can affect pH<\/li>\n\n\n\n<li>Use of pads or tampons that can cause irritation\/allergic reaction<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"physical\">Physical Exam<\/h3>\n\n\n\n<p><em>Step 1: LOOK at the Vulva and Skin Surrounding the Anus<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rule out skin dermatosis by evaluating for signs of chronic inflammation\n<ul class=\"wp-block-list\">\n<li>Erythema<\/li>\n\n\n\n<li>Hypo- or hyperpigmentation<\/li>\n\n\n\n<li>Papules and plaques<\/li>\n\n\n\n<li>Edema<\/li>\n\n\n\n<li>Architectural changes<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Step 2: Speculum Exam<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Obtain samples of vaginal discharge from vaginal walls or fornix\n<ul class=\"wp-block-list\">\n<li>BV: Thin | Homogenous | Often with odor<\/li>\n\n\n\n<li><em>Candida<\/em>: Thick | Chunky | White<\/li>\n\n\n\n<li><em>Trichomonas<\/em>: Green-yellow | Often bubbly<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Obtain sample for pH<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"point-of-care\">Clinical &#x2018;Point of Care&#x2019; Testing<\/h3>\n\n\n\n<p><em>pH Test<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Use swab from middle of vagina to avoid collection of semen, cervical mucus<\/li>\n\n\n\n<li>Place on narrow-range pH paper<\/li>\n\n\n\n<li>Not highly specific<\/li>\n\n\n\n<li>BV and <em>Trichomonas<\/em> have elevated pH &gt; 4.5<\/li>\n\n\n\n<li><em>Candida<\/em> &lt; 4.5<\/li>\n<\/ul>\n\n\n\n<p><em>Wet Mount or Saline Microscopy<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Coverslips should be placed on the slides and examined at 20x and 40x of microscope in office or laboratory\n<ul class=\"wp-block-list\">\n<li>Slide 1: Dilute discharge with 1 to 2 drops of 0.9% normal saline<\/li>\n\n\n\n<li>Slide 2: Dilute discharge with 10% KOH (for BV &#x2018;<span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Whiff test&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Fishy odor of vaginal discharge before or after addition of 10% KOH&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Whiff test<\/span>&#x2019; &#x2013; see below)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Look to identify: Clue cells | Budding yeast\/pseudohyphae | Motile trichomonads<\/li>\n\n\n\n<li>Test performance\n<ul class=\"wp-block-list\">\n<li>Results are immediate, inexpensive<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> (broad range due to clinician ability)<\/li>\n\n\n\n<li>BV: 37% to 70% | 94 to 99%<\/li>\n\n\n\n<li><em>Candida<\/em>: 53 to 61% | 89 to 91%<\/li>\n\n\n\n<li><em>Trichomonas<\/em>: 50 to 75% | 99%<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> increases slightly when in-clinic tests combined with history, signs and symptoms<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Noninfectious etiologies like desquamative inflammatory vaginitis can ONLY be diagnosed by wet mount\n<ul class=\"wp-block-list\">\n<li>Increased number of white blood cells and round parabasal epithelial cells<\/li>\n\n\n\n<li>Elevated pH<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Note: <\/strong>Many physician offices no longer have microscopes and\/or healthcare professionals are not trained at this type of diagnosis<\/p>\n\n\n\n<p><em>Amsel&#x2019;s Criteria and KOH <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Whiff test&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Fishy odor of vaginal discharge before or after addition of 10% KOH&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Whiff Test<\/span> (BV)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dilute vaginal discharge with 1-2 drops of 10% KOH and evaluate for amine or &#x201C;fishy&#x201D; odor<\/li>\n\n\n\n<li>Part of Amsel&#x2019;s diagnostic criteria for bacterial vaginosis: Must have 3 of the following symptoms\/signs\n<ul class=\"wp-block-list\">\n<li>Homogenous, thin, white discharge that smoothly coats the vaginal walls<\/li>\n\n\n\n<li>&gt;20% Clue cells (vaginal epithelial cells studded with adherent coccobacilli) on microscopic examination<\/li>\n\n\n\n<li>pH of vaginal fluid &gt;4.5<\/li>\n\n\n\n<li>Positive <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Whiff test&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Fishy odor of vaginal discharge before or after addition of 10% KOH&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Whiff Test<\/span><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> 92% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 77% (Amsel&#x2019;s criteria)<\/li>\n\n\n\n<li>Amsel&#x2019;s criteria is the recommended method of diagnosis (along with Gram stain\/Nugent scoring)<\/li>\n<\/ul>\n\n\n\n<p><em>Chromogenic BV Test (OSOM BV Blue POC test)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Measures sialidase levels in vaginal fluid<\/li>\n\n\n\n<li>Sialidase is produced by <em>Gardnerella<\/em> and <em>Bacteroides<\/em><\/li>\n\n\n\n<li>Dipstick with results in 10 min<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> 88 to 94% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span>&#xA0; 91 to 98%<\/li>\n<\/ul>\n\n\n\n<p><em>Rapid antigen test for Trichomonas vaginalis (OSOM Trichomonas POC test)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rapid antigen test to <em>Trichomonas<\/em> membrane proteins<\/li>\n\n\n\n<li>Results in 10 min<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> 88.3% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 98.8%<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"laboratory\">Laboratory Testing<\/h3>\n\n\n\n<p><em><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Nugent score&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The Nugent score, can be used by microbiologists to assess bacterial vaginosis.&#xA0; Assesses large Gram-positive rods (Lactobacillus), small Gram-variable rods (Gardnerella vaginalis) and curved Gram-variable rods (Mobiluncus) are scored and total score can range from 0 to 10. A score of 7 to 10 is consistent with bacterial vaginosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Nugent score<\/span> (BV)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gram stain looking at different types of bacteria associated with BV including\n<ul class=\"wp-block-list\">\n<li>Gram positive rods (lactobacilli)<\/li>\n\n\n\n<li>Gram negative and gram variable rods and cocci (<em>Gardnerella vaginalis, Prevotella, porphyromonas, peptostreptococci<\/em>)<\/li>\n\n\n\n<li>Curved Gram-negative rods (<em>mobiliuncus<\/em>)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Scores are based on presence of each these bacteria\n<ul class=\"wp-block-list\">\n<li>Normal flora: 0 to 3<\/li>\n\n\n\n<li>Intermediate flora: 4 to 6<\/li>\n\n\n\n<li>BV: 7 to 10<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Inexpensive | However, usually not same day results<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> 65 to 97% <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 71 to 81%<\/li>\n<\/ul>\n\n\n\n<p><strong>Note: <\/strong>Although recommended for diagnosis, mostly used for research purposes and rarely used in clinical practice<\/p>\n\n\n\n<p><em>Yeast Culture<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Indication: Recurrent yeast infections to speciate\n<ul class=\"wp-block-list\">\n<li>10-20% of women have <em>Candida<\/em> sp. in their vaginas and are asymptomatic so a positive culture without symptoms is not an indication for treatment<\/li>\n\n\n\n<li>Can detect specific species<\/li>\n\n\n\n<li>Can take several days to a week to get results<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Trichomonas<\/em> culture<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Not used frequently now that molecular diagnostics are available\n<ul class=\"wp-block-list\">\n<li>Less sensitive than newer tests<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Takes 5 days<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> 75 to 95% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 100%<\/li>\n<\/ul>\n\n\n\n<p><em>Pap Test<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Do not use for the diagnosis of vaginitis<\/li>\n\n\n\n<li>Confirm diagnosis by another method if patient is symptomatic and treat accordingly<\/li>\n\n\n\n<li>If asymptomatic with findings suggestive of BV or yeast, no indication to treat<\/li>\n\n\n\n<li>If asymptomatic with findings of <em>Trichomonas<\/em>, perform confirmatory diagnostic test and treat accordingly if positive | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span> only 55 to 60% for trichomonas diagnosis<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"commercial\">Commercial Testing<\/h3>\n\n\n\n<p><em><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;DNA&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The DNA molecule consists of two strands that wind around one another to form a shape known as a double helix. Each strand has a backbone made of alternating sugar (deoxyribose) and phosphate groups. Attached to each sugar is one of four bases--adenine (A), cytosine (C), guanine (G), and thymine (T). The two strands are held together by bonds between the bases; adenine bonds with thymine, and cytosine bonds with guanine. The sequence of the bases along the backbones serves as instructions for assembling protein and RNA molecules. (NIH: National Human Genome Research Institute)&amp;lt;br \/&amp;gt;&amp;lt;img class=&amp;quot;alignnone wp-image-445&amp;quot; src=&amp;quot;http:\/\/obgprojectdev.wpengine.com\/wp-content\/uploads\/2016\/07\/dna-300x120.png&amp;quot; alt=&amp;quot;dna&amp;quot; width=&amp;quot;223&amp;quot; height=&amp;quot;89&amp;quot; \/&amp;gt;&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">DNA<\/span> testing (Affirm VP Assay from BD)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Direct <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;DNA&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The DNA molecule consists of two strands that wind around one another to form a shape known as a double helix. Each strand has a backbone made of alternating sugar (deoxyribose) and phosphate groups. Attached to each sugar is one of four bases--adenine (A), cytosine (C), guanine (G), and thymine (T). The two strands are held together by bonds between the bases; adenine bonds with thymine, and cytosine bonds with guanine. The sequence of the bases along the backbones serves as instructions for assembling protein and RNA molecules. (NIH: National Human Genome Research Institute)&amp;lt;br \/&amp;gt;&amp;lt;img class=&amp;quot;alignnone wp-image-445&amp;quot; src=&amp;quot;http:\/\/obgprojectdev.wpengine.com\/wp-content\/uploads\/2016\/07\/dna-300x120.png&amp;quot; alt=&amp;quot;dna&amp;quot; width=&amp;quot;223&amp;quot; height=&amp;quot;89&amp;quot; \/&amp;gt;&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">DNA<\/span> probe to specific sequences of <em>Gardnerella vaginalis, Candida<\/em> spp, and <em>Trichomonas<\/em><\/li>\n\n\n\n<li>Must be sent out to lab<\/li>\n\n\n\n<li>However\n<ul class=\"wp-block-list\">\n<li>BV: Detection specific for <em>G vaginalis<\/em> only | Does not test for other bacterial species associated with BV | BV is polymicrobial condition and presence of 1 bacteria does not always indicate BV and can be part of normal flora, lowering <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">specificity<\/span><\/li>\n\n\n\n<li><em>Candida<\/em>: Tests for the presence of several <em>Candida<\/em> sp. but does not speciate<\/li>\n\n\n\n<li><em>Trichomonas: <\/em><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span> is the recommended test (see below) and not <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;DNA&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The DNA molecule consists of two strands that wind around one another to form a shape known as a double helix. Each strand has a backbone made of alternating sugar (deoxyribose) and phosphate groups. Attached to each sugar is one of four bases--adenine (A), cytosine (C), guanine (G), and thymine (T). The two strands are held together by bonds between the bases; adenine bonds with thymine, and cytosine bonds with guanine. The sequence of the bases along the backbones serves as instructions for assembling protein and RNA molecules. (NIH: National Human Genome Research Institute)&amp;lt;br \/&amp;gt;&amp;lt;img class=&amp;quot;alignnone wp-image-445&amp;quot; src=&amp;quot;http:\/\/obgprojectdev.wpengine.com\/wp-content\/uploads\/2016\/07\/dna-300x120.png&amp;quot; alt=&amp;quot;dna&amp;quot; width=&amp;quot;223&amp;quot; height=&amp;quot;89&amp;quot; \/&amp;gt;&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">DNA<\/span> testing<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span>\/<span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span>\n<ul class=\"wp-block-list\">\n<li>BV: 90.1% | 67.6%<\/li>\n\n\n\n<li><em>Candida:<\/em> 58.1% | 100%<\/li>\n\n\n\n<li><em>Trichomonas:<\/em> 46.3% | 100%<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>Nucleic Acid Amplification Tests (<span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Single swab panel test combining nucleic acid probe technology and multiplex PCR\n<ul class=\"wp-block-list\">\n<li>Several tests exist including NuSwab (LapCorp), SureSwab (Quest), Aptima (Hologic), BD Max Vaginal panel (Becton Dickinson), OneSwab (Medical Diagnostic Laboratory)<\/li>\n\n\n\n<li>Detects BV, Candida and Trichomonas | Can also detect Chlamydia trachomatis and Neisseria gonorrhoeae if desired<\/li>\n\n\n\n<li>Must be sent out to lab<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>BV\n<ul class=\"wp-block-list\">\n<li>Can detect multiple species of bacteria associated with bacterial vaginosis<\/li>\n\n\n\n<li>Most offer detection of common bacterial vaginosis associated bacteria including Atopobium vaginae, fastidious bacteria termed BV-associated bacterium (BVAB2), Megasphera type 1, and G. vaginalis<\/li>\n\n\n\n<li>Usually also detect some lactobacilli species that are negative predictors of BV like L. crispatus and L. jensenii<\/li>\n\n\n\n<li>The specific species tested varies per brand of test<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><em>Candida<\/em>\n<ul class=\"wp-block-list\">\n<li>Can detect and speciate multiple species of candida<\/li>\n\n\n\n<li>All test for C. albicans and C. glabrata<\/li>\n\n\n\n<li>Larger multi species candida test available for C. parapsilosis, C krusei, C tropicalis, C lusitaniae<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><em>Trichomonas<\/em>\n<ul class=\"wp-block-list\">\n<li>Can detect Trichomonas and is the recommended method for testing<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Sensitivity<\/span>\/<span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span>\n<ul class=\"wp-block-list\">\n<li>BV: 90 to 100% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 91 to 100%<\/li>\n\n\n\n<li>Candida: 84.7 to 97.7% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 93.2 to 99.1%<\/li>\n\n\n\n<li>Trichomonas: 95.3 to 100% | <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">Specificity<\/span> 95.2 to 100%<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"criteria\">Professional Recommendations:  Diagnostic Clinical Criteria <\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;ACOG&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;The American College of Obstetricians and Gynecologists&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">ACOG<\/span> does describe and recommend point of care testing in the office (summarized below), but also acknowledges that because pH paper, KOH and microscopy may not be generally available<\/li>\n<\/ul>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><strong>Commercial tests that have been approved by the U.S. Food and Drug Administration (<span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;FDA&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;U.S. Food and Drug Administration&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">FDA<\/span>) for the diagnosis of vaginitis can be used as an alternative to clinical testing<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p><em>BV<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Amsel&#x2019;s criteria with saline microscopy and KOH <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Whiff test&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Fishy odor of vaginal discharge before or after addition of 10% KOH&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">whiff test<\/span>, and gram stain with Nugent scoring<\/li>\n\n\n\n<li>Consider alternative FDA-approved commercial tests<\/li>\n<\/ul>\n\n\n\n<p><em>Candida<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In symptomatic patient must have one of the following\n<ul class=\"wp-block-list\">\n<li>Spores, hyphae, or pseudohyphae on saline\/KOH microscopy<\/li>\n\n\n\n<li>Positive yeast culture<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Consider alternative FDA-approved commercial tests<\/li>\n<\/ul>\n\n\n\n<p><em>Trichomonas<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"back-to-case\">Back to the Case<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Exam\n<ul class=\"wp-block-list\">\n<li>Vulva: Erythema and edema bilaterally<\/li>\n\n\n\n<li>Vaginal: Erythema<\/li>\n\n\n\n<li>White discharge present | Some left-over antifungal cream<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Diagnostic testing\n<ul class=\"wp-block-list\">\n<li>PH &lt; 4.5<\/li>\n\n\n\n<li>Saline microscopy and KOH: Increased WBCs but no obvious hyphae | More difficult to perform because of antifungal cream in vagina<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span> sent for vaginitis panel of BV, Candida albicans\/glabrata, trichomonas<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Result\n<ul class=\"wp-block-list\">\n<li>Candida albicans<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Treatment\n<ul class=\"wp-block-list\">\n<li>Cessation of intravaginal antifungal<\/li>\n\n\n\n<li>Patient switched to oral fluconazole<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Note: <\/strong>In this case, patient was switched to oral fluconazole because she seemed to have a contact dermatitis from the vaginal anti-fungal | Can happen in approximately 5% of OTC users | Many patients prefer oral anti-fungal as it is equally effective, well tolerated, and allergic reactions are rare&#xA0;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"wrap-up\">The Wrap-Up on Diagnostic Testing<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Accurate diagnosis is important, so avoid treating based on symptoms alone as this approach leads to misdiagnosis and inaccurate treatment which have consequences\n<ul class=\"wp-block-list\">\n<li>Increased cost<\/li>\n\n\n\n<li>Symptoms continue and return visits are inevitable<\/li>\n\n\n\n<li>Loss of trust<\/li>\n\n\n\n<li>Ongoing infection that can lead to complications including acquiring HIV or other STIs<\/li>\n\n\n\n<li>Overuse of antibiotics for nonexistent bacterial infections that can contribute to vaginal candidiasis and increased risk of azole resistance<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Self-diagnosis by the patient is not recommended due to limited accuracy<\/li>\n\n\n\n<li>Vaginitis may go undiagnosed, so it is important to consider other non-infectious diagnoses such as\n<ul class=\"wp-block-list\">\n<li>Vulvar skin diseases | Desquamative inflammatory vaginitis | Genitourinary syndrome of menopause<\/li>\n\n\n\n<li>It is important to distinguish vulvar symptoms from vaginal symptoms<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>This patient was evaluated in the office, including a physical exam\n<ul class=\"wp-block-list\">\n<li>No evidence of non-infectious cause<\/li>\n\n\n\n<li>On wet mount<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Why was <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span> testing performed?\n<ul class=\"wp-block-list\">\n<li>In-office testing with microscopy is quickest but not necessarily most accurate as it depends on both (1) clinician ability and (2) equipment availability<\/li>\n\n\n\n<li>For uncomplicated vaginitis especially with a classic presentation, office testing with pH and saline microscopy can be used if trained personnel and well-maintained equipment are both available<\/li>\n\n\n\n<li><span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span> test performed in this case because, even in the setting of adequate equipment and trained personnel, the patient had previously failed treatment leaving diagnosis in doubt or necessitating a different approach<\/li>\n\n\n\n<li>Especially in the case of more complicated vaginitis presentations (recurrent disease, severe symptoms, or previous failed treatment) consider <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;NAAT&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Nucleic acid amplification test (NAAT) is a molecular test capable of amplifying and measuring even minute amounts of DNA or RNA from a known pathogen, such as a virus or bacterium. Advantages include the ability to detect the presence of a pathogen early, even before an immune response has generated antibodies. The test is very sensitive and specific but clinical judgement is still important in making a diagnosis.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">NAAT<\/span> as it has higher <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Sensitivity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true positive rate. Measures the proportion of positives that are correctly identified as such (e.g., the percentage of&#xA0; people with the disorder of interest who are correctly identified as having the condition). Calculated as TP\/TP+FN where TP is true positives (have the disease and test positive) and FN is false negatives (have the disease, test negative).&#xA0; Helpful when you know how many laboratory samples&#xA0;are&#xA0;truly positive for disease&#xA0;and you want to know how many of these will be detected. However, in an office setting, you are typically screening otherwise normal individuals and do not know who does and who does not have a condition.&#xA0; Therefore, positive predictive value (PPV)&#xA0;becomes very important as this answers the meaningful clinical question of what is the chance that an otherwise healthy individual actually has the condition if the screening test is positive.&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">sensitivity<\/span> and <span class=\"glossaryLink\" aria-describedby=\"tt\" data-cmtooltip=\"&lt;div class=glossaryItemTitle&gt;Specificity&lt;\/div&gt;&lt;div class=glossaryItemBody&gt;Also called the true negative rate. Measures the proportion of negatives that are correctly identified as such (e.g., the percentage of healthy people are correctly identified as not having the condition). Calculated as TN\/TN+FP where TN is true negative (test negative, don&amp;#039;t have the disease) and FP is false positive (test positive, don&amp;#039;t have the disease).&lt;\/div&gt;\" data-mobile-support=\"0\" data-gt-translate-attributes='[{\"attribute\":\"data-cmtooltip\", \"format\":\"html\"}]' tabindex=\"0\" role=\"link\">specificity<\/span> | Counsel patient that there may be a delay for return of results but that accurate results will determine appropriate treatment<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Note: <\/strong>Treatment Guidelines can be found in &#x2018;Related ObG Topics&#x2019; below<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"references\">REFERENCES:&#xA0;<\/h2>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31856118\/\" target=\"_blank\" rel=\"noreferrer noopener\">ACOG Practice Bulletin 215:&#xA0; Vaginitis in Nonpregnant Patients<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/jcm.asm.org\/content\/58\/2\/e01643-19\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical validation of the Aptima Bacterial Vaginosis and Aptima Candida\/Trichomonas Vaginitis Assays: Results from a Prospective Multicenter Clinical Study (Schwebke et al. JCM, 2020) <\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5971525\/pdf\/e00252-18.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Diagnostic Performance of Molecular test vs clinician assessment of vaginitis (Schwebke et al. JCM, 2018)<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciaa260\/5826163\" target=\"_blank\" rel=\"noreferrer noopener\">Diagnosis and Treatment of Vaginal Discharge Syndromes in Community Practice Settings (Hillier et al.&#xA0; Clinical Infectious Diseases, 2020)&#xA0; &#xA0;<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/academic.oup.com\/cid\/advance-article-abstract\/doi\/10.1093\/cid\/ciaa267\/5826164?redirectedFrom=fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">Syndromic Treatment of Women with Vulvovaginal Symptoms in the United States: A call to Action! (Sobel, Jack. Clinical Infectious Diseases, 2020)&#xA0;<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/jcm.asm.org\/content\/56\/9\/e00342-18\" target=\"_blank\" rel=\"noreferrer noopener\">Molecular Diagnosis of Bacterial Vaginosis: an Update (Coleman et al, JCM, 2018) <\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23985917\/\" target=\"_blank\" rel=\"noreferrer noopener\">Comparison of Nucleic Acid Amplification Assays with BD Affirm VPIII and Diagnosis of Vaginitis in Symptomatic Women (Cartwright et al. JCM, 2013)<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5723541\/pdf\/nihms907923.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Rapid and POC tests for the diagnosis of Trichomonas Vaginalis in women and men (Gaydos et al. Sexually Transmitted Infections, 2017)<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5635603\/pdf\/nihms907885.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical Validation of a Test for the Diagnosis of Vaginitis (Gaydos et al, Obstetrics and Gynecology, 2017) <\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"related\">Related ObG Topics:<\/h2>\n\n\n\n<p><a href=\"https:\/\/www.obgproject.com\/2016\/10\/18\/trichomoniasis-cdc-diagnosis-treatment-guidelines\/\" target=\"_blank\" rel=\"noreferrer noopener\">Trichomoniasis: CDC Diagnosis and Treatment Guidelines &#x2013; The ObG Project<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.obgproject.com\/2018\/12\/20\/diagnosis-and-treatment-of-vulvovaginal-candidiasis\/\" target=\"_blank\" rel=\"noreferrer noopener\">Diagnosis and Treatment of Vulvovaginal Candidiasis &#x2013; The ObG Project<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.obgproject.com\/2016\/10\/16\/bv-cdc-diagnosis-treatment-recommendations\/\" target=\"_blank\" rel=\"noreferrer noopener\">Bacterial Vaginosis &#x2013; CDC Diagnosis and Treatment Recommendations &#x2013; The ObG Project<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Commercial Support&#xA0;<\/h3>\n\n\n\n<p>This educational activity is supported by Hologic<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Faculty Disclosures<\/h3>\n\n\n\n<p>Dr. Fuller reports that she has no relevant financial relationships to disclose<\/p>\n\n\n\n<div class=\"survey-link-wrap\"><a href=\"https:\/\/us13.list-Manage.com\/survey?u=2c7251a6306a3af3dcfc276b8&amp;id=6c56573f15\" target=\"blank\" class=\"btn\">PLEASE EVALUATE YOUR EDUCATIONAL EXPERIENCE &#xBB;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Review the latest recommendations with Ashley Fuller, MD, FACOG, NCMP.<br \/>\nVaginitis is inflammation or infection of the vagina associated with a spectrum of symptoms and a common reason for visits to both primary care doctors and OB\/GYNs<\/p>\n","protected":false},"author":6,"featured_media":310,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-curbside"],"acf":[],"featured_image_urls_v2":{"full":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"thumbnail":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured-150x150.jpg",150,150,true],"medium":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured-300x199.jpg",300,199,true],"medium_large":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"large":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"1536x1536":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"2048x2048":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"ultp_layout_landscape_large":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"ultp_layout_landscape":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"ultp_layout_portrait":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"ultp_layout_square":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"woocommerce_thumbnail":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",300,199,false],"woocommerce_single":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured.jpg",400,265,false],"woocommerce_gallery_thumbnail":["https:\/\/obgconnect.com\/curbside\/wp-content\/uploads\/sites\/4\/2020\/11\/alexandru-goman-612416-unsplash-featured-100x100.jpg",100,100,true]},"post_excerpt_stackable_v2":"<p>Review the latest recommendations with Ashley Fuller, MD, FACOG, NCMP.<br \/>\nVaginitis is inflammation or infection of the vagina associated with a spectrum of symptoms and a common reason for visits to both primary care doctors and OB\/GYNs<\/p>\n","category_list_v2":"<a href=\"https:\/\/obgconnect.com\/curbside\/category\/curbside\/\" rel=\"category tag\">Curbside Consult<\/a>","author_info_v2":{"name":"mharris","url":"https:\/\/obgconnect.com\/curbside\/author\/mharris\/"},"comments_num_v2":"0 comments","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Is it BV? 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